Longevity & Cellular
Epithalon
Also published as Epitalon, AEDG peptide, Ala-Glu-Asp-Gly
A four residue peptide developed as a synthetic stand in for Epithalamin, an extract of bovine pineal gland. It is the compound most associated with telomere and pineal research in this catalogue.
Where it came from
Developed by Vladimir Khavinson and the St Petersburg Institute of Bioregulation and Gerontology, part of a long running Russian programme on short regulatory peptides.
What the literature examines
- Telomerase activity in human somatic cell culture
- Melatonin rhythm and pineal function in aged animals
- Lifespan and tumour incidence in rodent colonies
- Chromatin and gene expression effects proposed for short peptides
State of the evidence
Long running human observation exists in the Russian literature, but not in a form that maps onto a modern controlled trial.
What a buyer should know
Nearly the entire evidence base comes from a single institute and a single research programme, much of it published in Russian language journals, with very little independent Western replication. That is not proof it is wrong, but it is a material fact any reseller should be able to state plainly.
Handling and stability
Very short, highly water soluble, supplied lyophilised. Short sequences of this kind degrade quickly in solution at room temperature.
Sequence
Ala-Glu-Asp-Gly
Read it yourself
We do not publish a curated citation list, because a hand picked list of papers is a sales tool. These links run a live query against the public databases, so you see everything, including the results that do not suit us.
Supplied for laboratory research use only. Nothing on this page is a dose, a protocol or a claim of effect in humans, and nothing here is medical advice. Read our research use policy.